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US 10,206,986 B2Granted
Annexin II variant compositions and methods
AssigneeRegents of the University of Minnesota
InventorsJohn R. Ohlfest, Michael R. Olin
Life of this patent
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Abstract
This disclosure describes polypeptides fragments of annexin II, variants thereof, compositions that includes such fragments and/or variants, and methods of using such frag and/or variants.
Claims19
A composition comprising an immunomodulatory annexin II variant comprising:
- a domain corresponding to amino acids 1-15 of SEQ ID NO:1, the domain comprising:
- at least one amino acid substitution compared to amino acids 1-15 of SEQ ID NO:1;
- and
- no more than two amino acid substitutions compared to amino acids 1-15 of SEQ ID NO:1.
1 more element
A method comprising:
- administering to a subject in need of such treatment an effective amount of a composition comprising an annexin II variant, the annexin II variant comprising:
- a domain corresponding to amino acids 1-15 of SEQ ID NO:1, the domain comprising:
- at least one amino acid substitution compared to amino acids 1-15 of SEQ ID NO:1;
- and
- no more than two amino acid substitutions compared to amino acids 1-15 of SEQ ID NO:1.
2 more elements
A method comprising:
- contacting dendritic cells with a composition comprising:
- an annexin II variant comprising:
- a domain corresponding to amino acids 1-15 of SEQ ID NO:1, the domain comprising:
- at least one amino acid substitution compared to amino acids 1-15 of SEQ ID NO:1;
- and
- no more than two amino acid substitutions compared to amino acids 1-15 of SEQ ID NO:1;
- and
- an antigen.
5 more elements
Dependencies are inferred from the claim text.