Attenuated Salmonella bacteria and methods of using
AssigneeCity of Hope
InventorsMohamed I. Husseiny Elsayed, Kevin Ferreri
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Abstract
Provided herein are attenuated Salmonella bacteria for expressing autoantigen alone or in combination with an immunomodulatory, as well as methods of using these bacteria to treat various autoimmune disorders.
Claims6
A method of treating an autoimmune disorder in a subject in need thereof comprising administering an attenuated Salmonella bacterium comprising a nucleic acid encoding a diabetic autoantigen and a nucleic acid encoding an immunomodulator, wherein expression of the diabetic autoantigen is under the control of an SPI2 promoter, and wherein administration of the attenuated Salmonella bacterium results in expression of the diabetic autoantigen and the immunomodulator in the subject.
Dependencies are inferred from the claim text.