Protein particles comprising disulfide crosslinkers and uses related thereto
AssigneesEmory University, Georgia Tech Research Corporation
InventorsAndrew S. Neish, Julie A. Champion
Life of this patent
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Abstract
This disclosure relates to particles comprising recombinant proteins, pharmaceutical composition comprising the particles, and therapeutic uses related thereto. In certain embodiments, the particles are made by the process of producing recombinant proteins and conjugating the recombinant proteins to form nanoparticles with a linking reagent comprising disulfide bonds. Typically the recombinant protein has a polypeptide of viral, fungal, or bacterial origin such as secreted effector proteins AvrA and YopJ. In certain embodiments, the disclosure relates to treating or preventing autoimmune diseases, cancer, or inflammatory diseases, or conditions such as inflammatory bowel disease (IBD).
Claims9
A method of treating an inflammatory disease comprising administering an effective amount of a pharmaceutical composition comprising particles comprising
- a) recombinant AvrA proteins;
- and
- b) linking groups comprising disulfide bonds,
- wherein the linking groups conjugate the recombinant AvrA proteins to form the particles, and wherein the size of the particles are between 50 nm and 200 nm in diameter, to a subject in need thereof.
Dependencies are inferred from the claim text.