Polypeptides binding to human complement C5
AssigneeSwedish Orphan Biovitrum AB (publ)
InventorsCharlotta Berghard, Magnus Berglund, Patrik Strömberg, Malin Lindborg, Elin Gunneriusson, Joachim Feldwisch
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Abstract
The present invention relates to C5 binding polypeptides, comprising a C5 binding motif, BM, which motif consists of an amino acid sequence selected from i) EX2X3X4A X6 X7EID X11LPNL X16X17X18QW X21AFIX25X26LX28D, and ii) an amino acid sequence which has at least 86% identity to the sequence defined in i), wherein the polypeptide binds to C5. The present invention moreover relates to C5 binding polypeptides for use in therapy, such as for use in treatment of a C5 related condition, and to methods of treatment.
Claims22
A fusion polypeptide comprising a C5 binding polypeptide, wherein the C5 binding polypeptide comprises a C5 binding motif, BM, which motif consists of an amino acid sequence selected from any one of SEQ ID NO:1-248, wherein said C5 binding motif forms part of two alpha helices with an interconnecting loop, within a three-helix bundle protein domain.
Dependencies are inferred from the claim text.