Compositions and methods for treating heart disease and/or injury
AssigneesCase Western Reserve University, Oregon Health & Science University
InventorsBradley T. Lang, Jerry Silver, Ryan Gardner, Beth Habecker
Life of this patent
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Abstract
A method of treating heart disease and/or injury in a subject includes administering to the subject a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of PTPσ.
Claims16
A method of treating heart disease or injury a subject in need thereof, the method comprising:
- administering to the subject a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of PTPσ, wherein the therapeutic agent comprises a therapeutic peptide with a sequence selected from the group consisting of SEQ ID NOs:
- 1-25 and 32.
A method of treating arrhythmia in a subject in need thereof, the method comprising:
- administering to cardiac tissue of the subject a therapeutically effective amount of a therapeutic agent that inhibits one or more of catalytic activity, signaling, and/or function of PTPσ, wherein the therapeutic agent comprises a therapeutic peptide with a sequence selected from the group consisting of SEQ ID NOs:
- 1-25 and 32.
A method of treating heart disease or injury in a subject in need thereof, the method comprising:
- administering to the subject a therapeutic agent that inhibits one or more of catalytic activity, signaling, and function of PTPσ, wherein the therapeutic agent comprises a therapeutic peptide that has at least about 85% sequence identity to the amino acid sequence of SEQ ID NO:
- 32.
A method of treating arrhythmia in a subject in need thereof, the method comprising:
- administering to cardiac tissue of the subject a therapeutically effective amount of a therapeutic agent that inhibits one or more of catalytic activity, signaling, and/or function of PTPσ, wherein the therapeutic agent comprises a therapeutic peptide that has at least about 85% sequence identity to the amino acid sequence of SEQ ID NO:
- 32.
Dependencies are inferred from the claim text.