Enhanced reconstitution and autoreconstitution of the hematopoietic compartment
AssigneeTaiga Biotechnologies, Inc.
InventorsBrian C. Turner, Yosef Refaeli, Gregory Alan Bird
Life of this patent
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Abstract
The present disclosure relates to the acceleration of hematopoietic compartment reconstitution in a subject in need of hematopoietic stem cell transplantation by administering a composition having a protein transduction domain-MYC (PTD-MYC) fusion protein in combination with hematopoietic stem cell transplantation and to the enhancement of hematopoietic compartment autoreconstitution in a subject in need thereof by administering a composition having a protein transduction domain-MYC (PTD-MYC) fusion protein.
Claims20
A method of enhancing hematopoietic compartment reconstitution in a subject suffering from a decrease in the amount of endogenous hematopoietic stem cells comprising:
- administering a therapeutically effective amount of a composition comprising a MYC-composition, a Bcl-2-composition, or both, to a subject suffering from a decrease in the amount of endogenous hematopoietic stem cells, wherein the MYC composition and the Bcl-2 composition each comprises a protein transduction domain (PTD), and wherein hematopoietic compartment reconstitution is enhanced compared to hematopoietic compartment reconstitution in a subject that is not administered the composition.
Dependencies are inferred from the claim text.