Topical compositions and methods of using the same
AssigneeNovan, Inc.
InventorsRyan Doxey, Jian Bao
Life of this patent
Estimating the term…
Abstract
The present invention generally relates to topical compositions and methods of using the same. The topical compositions may comprise a hydrophilic composition and a hydrophobic composition in admixture. The hydrophobic composition may include a nitric oxide-releasing compound such as, for example, a diazeniumdiolate functionalized co-condensed silica particle. In some embodiments, the topical composition may be self-emulsifying. Further described herein are kits comprising a hydrophilic composition and a hydrophobic composition.
Claims22
A topical composition comprising a hydrophilic composition and a hydrophobic composition in admixture;
- wherein the hydrophilic composition is a hydrogel and comprises a polymer, polyhydric alcohol, and water, wherein water is present in an amount of about 50% to about 99% by weight of the hydrophilic composition;
- wherein the hydrophobic composition comprises an active pharmaceutical ingredient, at least one hydrophobic base and at least one amphiphilic compound and/or emulsifying agent, wherein the active pharmaceutical ingredient comprises a diazeniumdiolate functionalized macromolecule;
- and
- wherein the topical composition is self-emulsifying and is an emulsion.
A kit comprising:
- a first composition comprising a hydrophilic composition;
- and
- a second composition comprising a hydrophobic composition,
- wherein the hydrophilic composition comprises a cellulose or a pharmaceutically acceptable salt thereof, a polyhydric alcohol, and water, wherein water is present in the hydrophilic composition in an amount of about 50% to about 99% by weight of the hydrophilic composition, and
- wherein the hydrophobic composition comprises an active pharmaceutical ingredient, an amphiphilic compound, and at least one hydrophobic base, and wherein the active pharmaceutical ingredient comprises a diazeniumdiolate functionalized macromolecule.
Dependencies are inferred from the claim text.