Bioactive coatings
AssigneeBioInteractions Ltd.
InventorsSimon Onis, Fanny Burrows, Krishan Kapoor, Alan Rhodes, Ajay Luthra
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Abstract
Antimicrobial and antithrombogenic polymer or polymeric blend, compounds, coatings, and materials containing the same, as well as articles made with, or coated with the same, and methods of making the same exhibiting improved antimicrobial properties and reduced platelet adhesion. Embodiments include polymers with antimicrobial and antithrombogenic groups bound to a single polymer backbone, an antimicrobial polymer blended with an antithrombogenic polymer, and medical devices coated with the antimicrobial and antithrombogenic polymer or polymeric blend.
Claims27
A compound comprising
- a random polymer of:
- (i) a heparin-poly(ethylene glycol) methacrylate monomer having a single heparin,
- (ii) methoxy(polyethylene glycol) methacrylate monomer,
- (iii) butyl methacrylate monomer and/or methacrylic acid monomer and/or benzoylphenyl methacrylate monomer;
- and
- (iv) poly(hexanide)-poly(ethylene glycol) methacrylate monomer and/or poly(hexanide) methacrylate monomer,
- with the polymer being free of crosslinks.
A method for making a polymer, the method comprising:
- polymerizing a mixture of:
- (i) heparin-poly(ethylene glycol) methacrylate monomer having a single heparin,
- (ii) methoxy(polyethylene glycol) methacrylate monomer,
- (iii) butylmethacrylate monomer and/or methacrylic acid monomer and/or benzovlphenyl methacrylate monomer;
- and
- (iv) poly(hexanide)-poly(ethylene glycol) methacrylate monomer and/or poly(hexanide) methacrylate monomer,
- with the polymer being made without crosslinks.
Dependencies are inferred from the claim text.