Anti-bacterial applications of poly-N-acetylglucosamine nanofibers
AssigneeMarine Polymer Technologies, Inc.
InventorsJohn N. Vournakis, Sergio Finkielsztein
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Abstract
Described herein are compositions comprising shortened fibers of poly-N-acetylglucosamine and/or a derivative thereof (“sNAG nanofibers”) and anti-bacterial applications of such compositions. The sNAG nanofibers may be formulated into compositions for the prevention and/or treatment of bacterial infections and diseases associated with such infections. Regimens employing such compositions are also described.
Claims20
A method for treating acne in a human subject, comprising topically applying a composition comprising shortened poly-β-1→4-N-acetylglucosamine fibers (“sNAG nanofibers”) to the skin of a human subject in need thereof, wherein the sNAG nanofibers comprise 70% or more than 70%, of N-acetylglucosamine monosaccharides, and wherein (i) more than 50% of the sNAG nanofibers are between 1 to 15 μm in length, or (ii) the sNAG nanofibers have a molecular weight between about 20 kDa to 75 kDa and treatment of a wound with the sNAG nanofibers does not elicit a detectable foreign body reaction in 14 days after treatment, and wherein the sNAG nanofibers do not have an effect, or substantially have no effect, on bacterial growth or survival of Staphylococcus aureus bacterial cultures in vitro.
A method for treating or preventing dermatitis caused by or associated with a bacterial infection in a human subject, comprising topically applying a composition comprising shortened poly-β-1→4-N-acetylglucosamine fibers (“sNAG nanofibers”) to the skin of a human subject in need thereof, wherein the sNAG nanofibers comprise 70% or more than 70%, of N-acetylglucosamine monosaccharides, and wherein (i) more than 50% of the sNAG nanofibers are between 1 to 15 gm in length, or (ii) the sNAG nanofibers have a molecular weight between about 20 kDa to 75 kDa and treatment of a wound with the sNAG nanofibers does not elicit a detectable foreign body reaction in 14 days after treatment, and wherein the sNAG nanofibers do not have an effect, or substantially have no effect, on bacterial growth or survival of Staphylococcus aureus bacterial cultures in vitro.
Dependencies are inferred from the claim text.