Therapeutic compounds and uses thereof

A compound of formula (Ia) or (If):

• or a salt thereof, wherein:
• X is NH;
• ring A is substituted with one or more groups Rb that are independently selected from the group consisting of Rc, —I, —NO2, —N(Rd)2, —CN, —C(O)—N(Rd)2, —S(O)—N(Rd)2, —S(O)2—N(Rd)2, —O—Rd, —S—Rd, —O—C(O)—Rd, —O—C(O)—O—Rd, —C(O)—Rd, —S(O)—Rd, —S(O)2—Rd, —O—C(O)—N(Rd)2, —N(Rd)—C(O)—ORd, —N(Rd)—C(O)—N(Rd)2, —N(Rd)—C(O)—Rd, —N(Rd)—S(O)—Rd, —N(Rd)—S(O)2—Rd, —N(Rd)—S(O)—N(Rd)2, —CH═C(Re)2, and —N(Rd)—S(O)2—N(Rd)2;
• each Rc is independently selected from the group consisting of C2-6alkenyl, C2-6 alkynyl, 3-20 membered carbocyclyl, 3-20 membered heterocyclyl, wherein any C1-6 alkyl, C2-6 alkenyl, C2-6alkynyl, 3-20 membered carbocyclyl, and 3-20 membered heterocyclyl is optionally substituted with one or more groups Rf;
• each Rf is independently selected from the group consisting of oxo, 3-20 membered carbocyclyl, 3-20 membered heterocyclyl, halo, —NO2, —N(Rg)2, —CN, —C(O)—N(Rg)2, —S(O)—N(Rg)2, —S(O)2—N(Rg)2, —O—Rg, —S—Rg, —O—C(O)—Rg, —C(O)—Rg, —C(O)—O—Rg, —S(O)—Rg, —S(O)2—Rg, —C(O)—N(Rg)2, —N(Rg)—C(O)—Rg, —Si(Rh)3, —N(Rg)—C(O)—O—Rg, —N(Rg)—S(O)—Rg, N(Rg)—S(O)2—Rg, and C1-6 alkyl, which 3-20 membered carbocyclyl, 3-20 membered heterocyclyl, and C1-6 alkyl are optionally substituted with one or more groups Ri,
• each Rg is independently selected from the group consisting of hydrogen, C1-6 alkyl, C2-6alkenyl, C2-6 alkynyl, 3-20 membered carbocyclyl, and 3-20 membered heterocyclyl, wherein each C1-6 alkyl, C2-6 alkenyl, C2-6alkynyl, C1-6 alkoxy, 3-20 membered carbocyclyl, and 3-20 membered heterocyclyl is optionally substituted with one or more groups Rj, or two Rg are taken together with the nitrogen to which they are attached to form a 3-20 membered heterocyclyl that is optionally substituted with one or more groups independently selected from the group consisting of oxo, halo and C1-3 alkyl that is optionally substituted with one or more groups independently selected from the group consisting of oxo and halo;
• each Rh is independently selected from the group consisting of H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-6 carbocyclyl;
• each Rj is independently selected from the group consisting of oxo, halo, amino, hydroxyl, —Si(Rk)3, 3-20 membered carbocyclyl, 3-20 membered heterocyclyl, and C1-C6 alkyl, wherein any 3-20 membered carbocyclyl, 3-20 membered heterocyclyl, and C1-C6 alkyl is optionally substituted with one or more groups independently selected from the group consisting of oxo, C1-C4alkyl, and halo;
• each Rk is independently selected from the group consisting of H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-6 carbocyclyl;
• each Ri is independently selected from the group consisting of oxo, halo, C1-6alkyl, cyano, —N(Rl)2, —S(O)—Rl, —S(O)2—Rl, —S(O)—N(Rl)2, —S(O)2—N(Rl)2, —N(Rl)—S(O)—Rl, —N(Rl)—C(O)—O—Rl, —N(Rl)—S(O)2—Rl, 3-20 membered heterocyclyl, and 3-20 membered carbocyclyl that is optionally substituted with one or more groups independently selected from the group consisting of halo, and C1-6alkyl;
• each Rl is independently selected from the group consisting of hydrogen, C1-6 alkyl, C2-6alkenyl, C2-6 alkynyl, 3-20 membered carbocyclyl, and 3-20 membered heterocyclyl, wherein each C1-6 alkyl, C2-6 alkenyl, C2-6alkynyl, C1-6 alkoxy, 3-20 membered carbocyclyl, and 3-20 membered heterocyclyl is optionally substituted with one or more groups Rm;
• or two Rl are taken together with the nitrogen to which they are attached to form a 3-20 membered heterocyclyl that is optionally substituted with one or more groups independently selected from the group consisting of oxo, halo and C1-3 alkyl that is optionally substituted with one or more groups independently selected from the group consisting of oxo and halo;
• and
• each Rm is independently selected from the group consisting of oxo, halo, amino, hydroxyl, —Si(Rn)3, 3-20 membered carbocyclyl, 3-20 membered heterocyclyl, and C1-C6 alkyl, wherein any 3-20 membered carbocyclyl, 3-20 membered heterocyclyl, and C1-C6 alkyl is optionally substituted with one or more groups independently selected from the group consisting of oxo, C1-C4alkyl, and halo;
• each Rn is independently selected from the group consisting of H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-6 carbocyclyl;
• each Rd is independently selected from the group consisting of hydrogen, C1-6 alkyl, C2-6alkenyl, C2-6 alkynyl, 3-20 membered carbocyclyl, and 3-20 membered heterocyclyl, wherein each C1-6 alkyl, C2-6 alkenyl, C2-6alkynyl, 3-20 membered carbocyclyl, and 3-20 membered heterocyclyl is optionally substituted with one or more groups Ro, or two Rd are taken together with the nitrogen to which they are attached to form a 3-20 membered heterocyclyl that is optionally substituted with one or more groups independently selected from the group consisting of oxo, halo and C1-3 alkyl that is optionally substituted with one or more groups independently selected from oxo and halo;
• each Ro is independently selected from the group consisting of oxo, halo, amino, hydroxyl, cyano, —O—Rp, 3-20 membered carbocyclyl, 3-20 membered heterocyclyl, and C1-C6 alkyl, wherein any C1-C6 alkyl, 3-20 membered carbocyclyl and 3-20 membered heterocyclyl is optionally substituted with one or more groups independently selected from the group consisting of oxo, C1-C4 alkyl, —O—Rq, and halo;
• each Rp is independently selected from the group consisting of hydrogen, C1-6 alkyl, C2-6alkenyl, C2-6 alkynyl, 3-20 membered carbocyclyl, and 3-20 membered heterocyclyl, wherein each C1-6 alkyl, C2-6 alkenyl, C2-6alkynyl, C1-6 alkoxy, 3-20 membered carbocyclyl, and 3-20 membered heterocyclyl is optionally substituted with one or more groups Rr,
• each Rr is independently selected from the group consisting of oxo, halo, amino, hydroxyl, —Si(Rs)3, 3-20 membered carbocyclyl, 3-20 membered heterocyclyl, and C1-C6 alkyl, wherein any 3-20 membered carbocyclyl, 3-20 membered heterocyclyl, and C1-C6 alkyl is optionally substituted with one or more groups independently selected from the group consisting of oxo, C1-C4alkyl, and halo;
• each Rs is independently selected from the group consisting of H, C1-6alkyl, C2-6alkenyl, C2-6 alkynyl, and C3-6 carbocyclyl;
• each Rq is independently selected from the group consisting of hydrogen, C1-6 alkyl, C2-6alkenyl, C2-6 alkynyl, 3-20 membered carbocyclyl, and 3-20 membered heterocyclyl, wherein each C1-6 alkyl, C2-6 alkenyl, C2-6alkynyl, C1-6 alkoxy, 3-20 membered carbocyclyl, and 3-20 membered heterocyclyl is optionally substituted with one or more groups Rt,
• each Rt is independently selected from the group consisting of oxo, halo, amino, hydroxyl, —Si(Ru)3, 3-20 membered carbocyclyl, 3-20 membered heterocyclyl, and C1-C6 alkyl, wherein any 3-20 membered carbocyclyl, 3-20 membered heterocyclyl, and C1-C6 alkyl is optionally substituted with one or more groups independently selected from the group consisting of oxo, C1-C4alkyl, and halo;
• each Ru is independently selected from the group consisting of H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-6 carbocyclyl;
• two Re groups taken together with the carbon to which they are attached form a 3-20 membered carbocyclyl;
• and
• Rb is: