Topical formulations of PDE-4 inhibitors and their methods of use
AssigneesEisai R&D Management Co., Ltd., Dermavant Sciences GmbH
InventorsAmbrish Vyas, Seiji Takemoto, Yoshihiro Akimoto
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Abstract
Embodiments herein are directed to topical formulations of a compound represented by the formula (I), salt, metabolite, prodrug, or hydrate thereof along with a solvent, and a base. The compound is a PDE4 inhibitor and the topical formulations may be used to treat dermatological conditions such as, but not limited to, atopic dermatitis, seborrheic dermatitis, alopecia, contact dermatitis, psoriasis, urticaria, eczema, burns, sunburn, pancreatitis, hepatitis, lichen planus, scleritis, scleroderma, dermatomyositis, itching associated with any of the preceding conditions or a combination thereof.
Claims40
A topical formulation comprising an effective amount of a compound represented by the formula (I), a salt thereof, or hydrate thereof,
- wherein R represents hydroxyl, C1-6 alkoxy optionally substituted with C1-6 alkoxy, or amino optionally substituted with C1-6 alkyl,
- a bleeding preventing agent, a solvent, and a base;
- wherein the topical formulation comprises about 30% to about 60% by weight of a solvent.
Dependencies are inferred from the claim text.