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US 10,206,924 B2Granted
Small molecule inhibitors of EGFR and PI3K
AssigneeThe Regents of the University of Michigan
InventorsChristopher Emil Whitehead, Judith S. Leopold
Life of this patent
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Abstract
This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a quinazoline structure or a quinoline structure which function as dual inhibitors of EGFR proteins and PI3K proteins, and their use as therapeutics for the treatment of cancer and other diseases.
Claims8
A compound described by Formula I:
- (Formula I), including pharmaceutically acceptable salts, solvates, or prodrugs thereof;
- wherein R1 is selected from the group consisting of:
- R2 is selected from:
- and wherein the compound inhibits at least one of an EGFR protein and a PI3K protein.
1 more element
Dependencies are inferred from the claim text.