Substituted pyrimidines for treatment of chronic cough, neuronal hypersensitivity underlying chronic cough, neuronal hypersensitivity underlying sub-acute cough and neuronal hypersensitivity underlying acute cough
AssigneeAfferent Pharmaceuticals, Inc.
InventorsAnthony P. Ford, Bruce G. McCarthy
Life of this patent
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Abstract
Methods for treating cough, chronic cough and urges to cough associated with respiratory diseases with a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein R1 and R2 are as defined herein.
Claims20
A method for treating chronic cough in a patient, the method comprising administering to the patient in need thereof an effective amount of a compound of Formula (I):
- or a pharmaceutically acceptable salt thereof,
- wherein:
- R1 is hydrogen or C1-C6 alkyl;
- and
- R2 is alkyl, alkenyl, alkynyl, amino, aminosulfonyl, halo, amido, haloalkyl, alkoxy, hydroxy, haloalkoxy, nitro, hydroxyalkyl, alkoxyalkyl, hydroxyalkoxy, alkynylalkoxy, alkylsulfonyl, arylsulfonyl, carboxyalkyl, cyano or alkylcarbonyl.
A method for treating neuronal hypersensitivity underlying acute cough, neuronal hypersensitivity underlying sub-acute cough, or neuronal hypersensitivity underlying chronic cough in a patient, the method comprising administering to the patient in need thereof an effective amount of a compound of Formula (I):
- or a pharmaceutically acceptable salt thereof,
- wherein:
- R1 is hydrogen or C1-C6 alkyl;
- and
- R2 is alkyl, alkenyl, amino, aminosulfonyl, halo, amido, haloalkyl, alkoxy, hydroxy, haloalkoxy, nitro, hydroxyalkyl, alkoxyalkyl, hydroxyalkoxy, alkynylalkoxy, alkylsulfonyl, arylsulfonyl, carboxyalkyl, cyano or alkylcarbonyl.
A method for treating chronic cough in a patient, the method comprising administering to the patient in need thereof an effective amount of a pharmaceutically acceptable salt of the following compound:
A method for treating neuronal hypersensitivity underlying acute cough, neuronal hypersensitivity underlying sub-acute cough, or neuronal hypersensitivity underlying chronic cough in a patient, the method comprising administering to the patient in need thereof an effective amount of a pharmaceutically acceptable salt of the following compound:
Dependencies are inferred from the claim text.