Complexes of Ivacaftor and its salts and derivatives, process for the preparation thereof and pharmaceutical compositions containing them

A stable complex comprising

• i. Ivacaftor, or a salt thereof;
• ii. at least one complexing agent which is copolymers of vinylpyrrolidone and vinyl acetate;
• and
• iii. a pharmaceutically acceptable excipient which is sodium lauryl sulfate;
• wherein said complex has a particle size is between 10 nm and 600 nm, and possesses one or more among the following features:
• a) is instantaneously redispersible in physiological relevant media;
• b) is stable in solid form and in colloid solution and/or dispersion;
• c) has an apparent solubility in water is of at least 1 mg/mL;
• d) has a parallel artificial membrane permeability assay (PAMPA) permeability of at least 0.4×10−6 cm/s when dispersed in distilled water, which does not decrease in time at least for 6 months;
• and
• e) exhibits no observable food effect.