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US 10,206,904 B2Granted
Licofelone derivatives and methods of use
AssigneeThe Board of Regents of the University of Oklahoma
InventorsChinthalapally V. Rao, Naveena B. Janakiram, Hariprasad Gali, Altaf Mohammed, Gopal Pathuri
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Abstract
Derivatives of licofelone for the treatment of chronic inflammatory diseases and epithelial cancers associated with chronic inflammation are disclosed. The agents target mPGES-1 and 5-LOX.
Claims9
A compound comprising the structural formula:
- wherein
- X is selected from the group consisting of F, Cl, Br, and I;
- and
- R1 and R2 are selected from the group consisting of:
- H, CH2(CH2)nOH, CH2(CH2)mCOOH, CH((CH2)mCH3)COOH, CH((CH2)nOH))COOH, CH((CH2)nCOOH)COOH, CH2(CH2)nNH2, CH((CH2)nCONH2)COOH, CH((CH2)nNH2)COOH, CH((CH2)nNHC(NH)NH2)COOH, and CH2(CH2)nF, wherein m=0-3 and n=1-3;
- and with the proviso that no more than one of R1 and R2 is H.
3 more elements
A method of treating an inflammatory-related disease or condition in a subject in need of such therapy, comprising:
- administering to the subject an effective amount of a compound comprising the structural formula:
- wherein
- X is selected from the group consisting of F, Cl, Br, and I;
- and
- R1 and R2 are selected from the group consisting of:
- H, CH2(CH2)nOH, CH2(CH2)mCOOH, CH((CH2)mCH3)COOH, CH((CH2)nOH))COOH, CH((CH2)nCOOH)COOH, CH2(CH2)nNH2, CH((CH2)nCONH2)COOH, CH((CH2)nNH2)COOH, CH((CH2)nNHC(NH)NH2)COOH, and CH2(CH2)nF, wherein m=0-3 and n=1-3;
- and with the proviso that no more than one of R1 and R2 is H.
4 more elements
Dependencies are inferred from the claim text.