US 10,206,902 B2 · Mono- or di-substituted indoles as dengue viral replication inhibitors

Abstract

The present invention concerns mono- or di-substituted indole compounds of formula (I) which are useful to prevent or treat dengue viral infections and also relates to said compounds for use as a medicine, more preferably for use as a medicine to treat or prevent dengue viral infections. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of dengue viral infections. The invention also relates to processes for preparation of the compounds.

Claims9

Dependent claims

A compound of formula (I)

wherein:
(1) R1 is H, R2 is F, and R3 is H, F or CH3;
(2) R1 is F or CH3, R2 is OCH3, and R3 is H;
(3) R1 is H, R2 is Cl, and R3 is H or CH3;
(4) R1 is F, R2 is H, and R3 is CH3;
(5) R1 is H, R2 is OCH3, and R3 is Cl;
(6) R1 is F, R2 is F, and R3 is H;
(7) R1 is H, R2 is OCH3, and R3 is CH3;
or
(8) R1 is CH3, R2 is H, and R3 is F;
or a stereo-isomeric form, a pharmaceutically acceptable salt, solvate or polymorph thereof.

8 more elements

Dependencies are inferred from the claim text.

Facts

Application

15/515,563Filed 30 Sep 2015

Priority

EP 141873731 Oct 2014

Published

US 2017/0224658 A110 Aug 2017

Granted

19 Feb 2019

Term ends

Not estimatedThe source records don’t support an estimate.

Classification16 codes

A61K 31/404
Condensed with carbocyclic rings, e.g. carbazole: indoles, e.g. pindolol
A61P 31/00
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A61P 31/12
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics: antivirals
A61P 31/14
Antivirals: for RNA viruses

Mono- or di-substituted indoles as dengue viral replication inhibitors

Life of this patent

Mono- or di-substituted indoles as dengue viral replication inhibitors

Life of this patent

Abstract

Claims9