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US 10,206,900 B2Granted
Treatments for fibrotic diseases
AssigneeMor Research Applications Ltd.
InventorsAyala Pollack, Zeev Dvashi
Life of this patent
Estimating the term…
Abstract
Disclosed herein are methods for treatment for fibrosis, ocular pathologies associated with fibrosis, including proliferative vitreoretinopathy (PVR) by inhibiting the activity of activated transforming growth factor β activated kinase 1 (TAK1), or activation thereof. Pharmaceutical compositions for use in the described treatments are also provided.
Claims3
A method for treatment of proliferative vitreoretinopathy (PVR), in a subject, comprising:
- administering to a subject in need thereof, a therapeutically effective amount of an inhibitor of at least one of the activation or kinase activity of transforming growth factor β activated kinase 1 (TAK-1),
- wherein the inhibitor is 5Z-7 oxozeaenol,
- thereby treating the PVR.
Dependencies are inferred from the claim text.