Creatine ester anti-inflammatory compounds and formulations
AssigneeBoard of Regents of the University of Nebraska
InventorsDonald W. Miller, Samuel C. Augustine, Jon C. Wagner, Thomas L. McDonald, Dennis H. Robinson
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Abstract
The present invention provides a creatine ester anti-inflammatory compound which may be received by animals and then metabolized into a biologically active form of creatine. The biologically active creatine inhibits the production of chemical mediators, released during an inflammatory response, which are important components in the inflammatory response and the inflammation and pain resulting from physical or chemical trauma to cells and tissue.
Claims18
A topical formulation comprising creatine ethyl ester, a creatine ethyl ester salt, or a combination thereof present in an amount of about 15 percent to about 25 percent by weight of the topical formulation.
A topical formulation comprising a penetrating agent and creatine ethyl ester, wherein the creatine ethyl ester is present in an amount of about 15 percent to about 25 percent by weight of the topical formulation, and wherein the penetrating agent comprises a lipophilic solvent, a nonionic surfactant, or a combination thereof.
A topical delivery vehicle for an animal comprising creatine ethyl ester, a creatine ethyl ester salt, or a combination thereof present in an amount of about 15 percent to about 25 percent by weight of the topical formulation, and wherein the vehicle is impregnated or adsorbed into a patch or wrap.
Dependencies are inferred from the claim text.