Microcapsules with polymeric coating comprising a lipid and an active agent

A microcapsule comprising a polymeric coating, the polymeric coating being at least partly crosslinked with a polymeric matrix comprising a polysaccharide, wherein a lipid having a melting point of at least 30° C. and an active agent or a prodrug or salt thereof are embedded in said matrix, which is obtained or obtainable by a method comprising

• (a) providing an aqueous solution for coating said microcapsule with a polymeric coat, wherein said aqueous solution comprises a polymer being comprised in the coating,
• (b) providing an aqueous composition comprising the polysaccharide,
• (c) forming an oil phase comprising the lipid having a melting point of at least 30° C. and the active agent or prodrug or salt thereof by heating the oil phase to the melting temperature of the lipid or above,
• (d) mixing the oil phase according to (c) with the aqueous composition according to (b), thereby forming an emulsion,
• (e) adding the emulsion according to (d) drop-wise to the aqueous solution according to (a), thereby forming the microcapsule, optionally adding the microcapsule to a crosslinking solution, and
• (f) isolating the microcapsule and drying the isolated microcapsule,
• wherein the lipid is chosen from hydrogenated coca-glycerides;
• and
• wherein the obtained microcapsule does not leak oil and is non-sticky.