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US 10,206,878 B2Granted
Lyophilized formulation of TAT-NR2B9C with acetylation scavenger
AssigneeNoNO Inc.
InventorsJonathan David Garman, Frieder Hofmann
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Abstract
The present invention provides lyophilized formulations of active agents, particularly of TAT-NR2B9c including histidine, trehalose and lysine. TAT-NR2B9c has shown promise for treating stroke, aneurysm, subarachnoid hemorrhage and other neurological or neurotraumatic conditions. Such formulations are stable at ambient temperature thus facilitating maintenance of supplies of such a formulation in ambulances for administration at the scene of illness or accident or in transit to a hospital.
Claims16
A prelyophilized formulation at a pH of 6-7 comprising:
- a peptide, which has the amino acid sequence of SEQ ID NO:
- 6 or SEQ ID NO:
- 7 or differs therefrom by up to 5 substitutions, deletions or insertions;
- histidine;
- trehalose;
- and
- lysine,
- wherein the peptide is at a concentration of 70-120 mg/ml, the concentration of histidine is 20-50 mM, the concentration of trehalose is 100-200 mM and the concentration of lysine is 700-750 mM.
5 more elements
Dependencies are inferred from the claim text.