Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases

A pharmaceutical composition comprising a blend of a first solid dispersion and a second solid dispersion,

• wherein the first solid dispersion comprises 70 wt % to 90 wt % of amorphous (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1) relative to the total weight of the first solid dispersion and 10 wt % to 30 wt % of hydroxypropyl methylcellulose relative to the total weight of the first solid dispersion,
• wherein the second solid dispersion comprises 70 wt % to 90 wt % of amorphous N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 2) relative to the total weight of the second solid dispersion, and
• wherein the pharmaceutical composition is a tablet which comprises 25 mg to 125 mg of Compound 1 and 100 mg to 200 mg of Compound 2.