Loading patent…
AssigneeAdvanced Bionutrition Corporation
InventorsMoti Harel, Qiong Tang, Trisha Rice, Kimberly Jennings, Brian Carpenter, Roger Drewes, Elizabeth Raditsis, January Scarbrough
Estimating the term…
Dry stabilizing compositions for bioactive materials include sugars and hydrolyzed proteins, and may be formed into tablets or other forms providing enhanced stability for the bioactive material. Compositions containing the bioactive materials may be produced by a method that includes (a) combining the bioactive material with other ingredients in an aqueous solvent to form a viscous slurry; (b) snap-freezing the slurry in liquid nitrogen to form solid frozen particles, beads, droplets or strings; (c) primary drying by water removal under vacuum of the product of step (b) while maintaining it at a temperature above its freezing temperature; and (d) secondary drying of the product of step (c) at maximum vacuum and a temperature of 20° C. or higher for a time sufficient to reduce the water activity to below 0.3 Aw.
A dry stabilizing composition in an amorphous glassy state, comprising a bioactive material, one or more disaccharides at 10-50%, one or more oligosaccharides at 10-80%, one or more polysaccharides at 0.1-10%, one or more hydrolyzed proteins at 0.5-40%, vitamin E, and one or more carboxylic acid salts, each percentage based on the total weight of the composition, wherein the bioactive material comprises one or more live microorganisms, and wherein the composition exhibits less than one log loss of Colony Forming Unit per gram (CFU/g) after 14 days at 40° C. and 43% relative humidity (RH).
A dry stabilizing composition in an amorphous glassy state, comprising a bioactive material, one or more disaccharides at 10-90%, one or more oligosaccharides at 1-10%, one or more polysaccharides at 0.1-10%, one or more hydrolyzed proteins at 0.5-40%, and one or more carboxylic acid salts, each percentage based on the total weight of the composition, wherein the bioactive material comprises one or more live microorganisms, and wherein the composition exhibits less than one log loss of Colony Forming Unit per gram (CFU/g) after 14 days at 40° C. and 43% relative humidity (RH).
Dependencies are inferred from the claim text.