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US 10,202,331 B2Granted
Antifibrinolytic compounds
OwnerBakshy A. Chibberinventor
Life of this patent
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Abstract
The present invention provides novel and antifibrinolytic compounds, processes for their preparation, pharmaceutical and veterinary compositions thereof, and their use in medicine, in particular for the treatment of bleeding. The present application relates to numerous embodiments of chemical structures which in whole or in part mimic or are analogs of the amino acid Lysine such that they bind to specific binding site(s) within specific protein sub structures in the structures of Plasminogen, and/or Plasmin, and/or Plasminogen Activators, and/or Thrombin.
Claims12
A compound of formula III:
- R1—CH2—X1—R5 (III)
- wherein:
- R1 is —S+R9R10;
- R5 is —C(O)R12, —SO2R13, —P(O)R14R15, nitro or nitroso;
- R9 and R10 are independently (C1-C4)alkyl or halo(C1-C4)alkyl;
- R12;
- R13, R14 and R15 are independently hydroxyl, —O—(C1-C4)alkyl or —(C1-C4)alkyl;
- and
- X1 is trans cyclohexan-1,4-diyl;
- with the proviso that R1 is not NH2 when R5 is COOH, or a pharmaceutically acceptable salt thereof.
7 more elements
Dependencies are inferred from the claim text.