Polyprenylated phloroglucinol compounds as potent P-glycoprotein inducers
AssigneeCouncil of Scientific and Industrial Research
InventorsSandip Bharate, Ajay Kumar, Jaideep Bharate, Prashant Joshi, Abubakar Wani, Ramesh Mudududdla, Rohit Sharma, Ram Vishwakarma
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Abstract
The present invention relates to the polyprenylated phloroglucinol compounds of formulae I and II. The present invention also provides synthesis and p-glycoprotein induction activity of the alkyl- and acyl-polyprenylated phloroglucinol compounds. Further, use of the compounds as p-glycoprotein inducers and methods of treatment of Alzheimer's disease using compounds of the invention are also provided.
Claims10
A compound having a structural formulae selected from:
The compound as claimed in 1, claim wherein compound 1b, 1g and 2b displayed EC50 of 8.9, 6.8 and 2.9 nM respectively.
Dependencies are inferred from the claim text.