Methods for selective oxidation of alpha tocotrienol in the presence of non-alpha tocotrienols
AssigneeBioelectron Technology Corporation
InventorPaul Mollard
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Abstract
A method of producing alpha-tocotrienol quinone or a stereoisomer thereof, the method comprising selective opening of alpha-tocotrienol chroman to alpha-tocotrienol quinone in the presence of non-alpha tocotrienol chromans by oxidizing alpha-to-cotrienol with a metal salt oxidizing agent, wherein the stoichiometric ratio of metal salt oxidizing agent/alpha-tocotrienol is at least 4:1 and wherein said metal oxidizing agent is added in sequential additions, in order to reduce oxidation of any amounts of non-alpha tocotrienol chromans that might have been present in the starting alpha-tocotrienol chroman material. This process uses conditions favoring oxidation rates of the alpha tocotrienol chroman vs. the non-alpha tocotrienol chromans.
Claims20
A method of producing alpha-tocotrienol quinone of Formula I:
- or a stereoisomer thereof, the method comprising oxidizing alpha-tocotrienol to alpha-tocotrienol quinone of Formula I, in the presence of one or more non-alpha-tocotrienols, with a metal salt oxidizing agent, wherein the metal salt oxidizing agent comprises at least one of iron(III) citrate and iron(III) tartrate, wherein the stoichiometric ratio of the metal salt oxidizing agent/alpha-tocotrienol is at least about 4:1, and wherein said metal salt oxidizing agent is added in sequential portion additions;
- or is added at a single point in time, in a single portion, and/or is added over 1, 2, 10, 15, 20, or 30 minutes.
Dependencies are inferred from the claim text.