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US 10,201,652 B2Granted
Acoustophoretic separation of lipid particles from red blood cells
AssigneeFloDesign Sonics, Inc.
InventorsBrian Dutra, Bart Lipkens, Daniel Kennedy, Michael J. Rust
Life of this patent
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Abstract
A system for removing lipids from blood during cardiopulmonary bypass surgery is disclosed. The system uses an acoustophoretic separator having improved trapping force. The transducer of the acoustophoretic seperator includes a ceramic crystal. Blood flows through the separator, and lipids are trapped and removed.
Claims15
A method of separating lipids from blood, the method comprising:
- flowing the blood through a flow chamber, wherein the flow chamber has a source of acoustic energy with an initial shape and, on an opposing side of the flow chamber, a reflector of acoustic energy, and wherein the blood contains lipids;
- driving the source of acoustic energy at a frequency that generates a higher order mode shape than the initial shape to create a plurality of three-dimensional standing waves in the blood;
- and
- removing lipids trapped in the three-dimensional standing waves from the blood;
- wherein each three-dimensional standing wave results in an acoustic radiation force with an axial force component and a lateral force component that are of the same order of magnitude.
2 more elements
A method of separating lipids from blood, the method comprising:
- flowing the blood through a flow chamber, wherein the flow chamber has a source of acoustic energy with an initial shape and, on an opposing side of the flow chamber, a reflector of acoustic energy, and wherein the blood contains lipids;
- driving the source of acoustic energy at a frequency that generates a higher order mode shape than the initial shape to create a plurality of three-dimensional standing waves in the blood;
- and
- removing lipids trapped in the three-dimensional standing waves from the blood;
- wherein each three-dimensional standing wave results in an acoustic radiation force with an axial force component and a lateral force component that are of the same order of magnitude;
- and
- wherein the source of acoustic energy is an ultrasonic transducer comprising:
- a housing with a top end, a bottom end, and an interior volume;
- and
- a crystal at the bottom end of the housing with an exposed exterior surface and an interior surface, the crystal being able to vibrate when driven by a voltage signal, wherein a backing layer contacts the interior surface of the crystal, the backing layer being made of a substantially acoustically transparent material.
7 more elements
Dependencies are inferred from the claim text.