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US 10,197,580 B2Granted
Biomarkers associated with schizophrenia
AssigneeCambridge Enterprises Limited
InventorsSabine Bahn, Man Kuan Chan
Life of this patent
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Abstract
The invention relates to biomarkers and methods of diagnosing or monitoring schizophrenia, or a predisposition thereto.
Claims27
A method comprising:
- (a) obtaining a test biological sample from an individual with prodromal syndrome;
- and
- (b) quantifying the amounts of a panel of biomarkers in the test biological sample,
- wherein the panel of biomarkers comprises Macrophage migration inhibitory factor (MIF), Pancreatic polypeptide (PPP), Apolipoprotein H (ApoH), Apolipoprotein A1 (ApoA1), Tenascin C (TNC), Interleukin-1 receptor antagonist (IL 1ra), Receptor for advanced glycosylation end products (RAGE), Interleukin 8 (IL 8), Haptoglobin, von Willebrand factor (VWF), Beta-2 microglobulin (B2M), Immunoglobulin A (IgA), Leptin, Testosterone (Total), Follicle-stimulating hormone (FSH), Thyroid stimulating hormone (TSH), Insulin-like growth factor-binding protein 2 (IGFBP2), AXL receptor tyrosine kinase (AXL), Stem Cell Factor (SCF), Factor VII (FVII) and Angiotensin-converting enzyme (ACE).
1 more element
A method comprising:
- a) obtaining a test biological sample from an individual with prodromal syndrome;
- and
- (b) quantifying the amounts of a panel of biomarkers in the test biological sample,
- wherein the panel of biomarkers comprises Macrophage migration inhibitory factor (MIF), Pancreatic polypeptide (PPP), Leptin, Factor VII (FVII), Haptoglobin, Receptor for advanced glycosylation end products (RAGE), Tenascin C (TNC), AXL receptor tyrosine kinase (AXL), Follicle-stimulating hormone (FSH), Insulin-like growth factor-binding protein 2 (IGFBP2), Interleukin-1 receptor antagonist (IL 1ra), Beta-2 microglobulin (B2M), Interleukin 8 (IL 8), Stem Cell Factor (SCF), von Willebrand factor (VWF), Angiotensin-converting enzyme (ACE), Apolipoprotein H (ApoH), Immunoglobulin A (IgA), Apolipoprotein A1 (ApoA1), Testosterone (Total), Thyroid stimulating hormone (TSH) and Alpha-2 Macroglobulin (A2M).
1 more element
A The method comprising:
- a) obtaining a test biological sample from an individual with prodromal syndrome;
- and
- (b) quantifying the amounts of a panel of biomarkers in the test biological sample,
- wherein the panel of biomarkers comprises Macrophage migration inhibitory factor (MIF), Pancreatic polypeptide (PPP), Leptin, Factor VII (FVII), Haptoglobin, Receptor for advanced glycosylation end products (RAGE), Tenascin C (TNC), AXL receptor tyrosine kinase (AXL), Follicle-stimulating hormone (FSH), Insulin-like growth factor-binding protein 2 (IGFBP2), Interleukin-1 receptor antagonist (IL 1ra), Beta-2 microglobulin (B2M), Interleukin 8 (IL 8), Stem Cell Factor (SCF), von Willebrand factor (VWF), Angiotensin-converting enzyme (ACE), Apolipoprotein H (ApoH), Immunoglobulin A (IgA), Apolipoprotein A1 (ApoA1), Testosterone (Total), Thyroid stimulating hormone (TSH), Carcinoembryonic antigen (CEA), Serum glutamic oxaloacetic transaminase (SGOT) and Interleukin-13 (IL 13).
1 more element
Dependencies are inferred from the claim text.