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US 10,196,629 B2Granted
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases
AssigneesaTyr Pharma, Inc., Pangu BioPharma Limited
InventorsLeslie Ann Greene, Kyle P. Chiang, Fei Hong, Alain P. Vasserot, Wing-Sze Lo, Jeffry D. Watkins, Cheryl L. Quinn, John D. Mendlein
Life of this patent
Estimating the term…
Abstract
Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications.
Claims8
A pharmaceutical composition, comprising an isolated polynucleotide that encodes the aminoacyl-tRNA synthetase (AARS) polypeptide that consists of SEQ ID NO:
- 151 or differs from SEQ ID NO:
- 151 by substitution, deletion, and/or addition of 1, 2, or 3 amino acids, wherein the polynucleotide is selected from (a) a cDNA polynucleotide and (b) a modified mRNA polynucleotide, and wherein the composition has less than about 10 EU endotoxin/mg protein.
Dependencies are inferred from the claim text.