Hepatitis B antiviral agents

A compound of Formula VI:

• or pharmaceutically acceptable salts thereof;
• wherein
• R4 is H or C1-C6 alkyl;
• G1 is H or C1-C6 alkyl;
• wherein each R5 is independently selected at each occurrence from the group consisting of C1-C6 alkyl, C1-C6 alkoxy, halo, —CN, —NO2, -(L)m-SR9, -(L)m-S(═O)R9, -(L)m-S(═O)2R9, -(L)m-NHS(═O)2R9, -(L)m-C(═O)R9, -(L)m-OC(═O)R9, -(L)mCO2R8, -(L)m-OCO2R8, -(L)m-CH(R8)2, -(L)m-N(R8)2, -(L)m-C(═O)N(R8)2, -(L)m-OC(═O)N(R8)2, -(L)m-NHC(═O)NH(R8), -(L)m-NHC(═O)R9, -(L)m-NHC(═O)OR9, -(L)m-C(OH)(R8)2, -(L)mC(NH2)(R8)2, —C1-C6 haloalkyl, —C1-C6 dihaloalkyl, and —C1-C6 trihaloalkyl;
• L is independently, at each occurrence, a bivalent radical selected from —(C1-C3 alkylene)-, —(C3-C7 cycloalkylene)-, —(C1-C3 alkylene)m-O—(C1-C3 alkylene)m-, or —(C1-C3 alkylene)m-NH—(C1-C3 alkylene)m-;
• each R8 is independently, at each occurrence, H, C1-C6 alkyl, —C1-C6 haloalkyl, —C1-C6 dihaloalkyl, —C1-C6 trihaloalkyl, C1-C6 heteroalkyl, C3-C10 cycloalkyl, C3-C10 heterocycloalkyl, aryl, heteroaryl, —C1-C4 alkyl-(C3-C10 cycloalkyl), —C1-C4 alkyl-(C3-C10 heterocycloalkyl), —C1-C4 alkyl-(aryl), or —C1-C4 alkyl(heteroaryl), and wherein the alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl is optionally substituted with 1-5 substituents selected from R2;
• R9 is C1-C6 alkyl, —C1-C6 haloalkyl, —C1-C6 dihaloalkyl, —C1-C6 trihaloalkyl, C1-C6 heteroalkyl, C3-C10 cycloalkyl, a C3-C10 heterocycloalkyl, aryl, heteroaryl, —C1-C4 alkyl-(C3-C10 cycloalkyl), —C1-C4 alkyl-(C3-C10 heterocycloalkyl), —C1-C4 alkyl-(aryl), or —C1-C4 alkyl-(heteroaryl), and wherein the alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl ring is optionally substituted with 1-5 substituents selected from R2;
• R10 is OH, C1-C6 alkyl, C1-C6 alkyl-OH, C1-C6 fluoroalkyl, C1-C6 heteroalkyl, C3-C10 cycloalkyl, a C3-C10 heterocycloalkyl, aryl, heteroaryl, —C1-C4 alkyl-(C3-C10 cycloalkyl), —C1-C4 alkyl-(C3-C10 heterocycloalkyl), —C1-C4 alkyl-(aryl), or —C1-C4 alkyl-(heteroaryl), and wherein the alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl ring is optionally substituted with 1-5 substituents selected from R2;
• R11 is a bond or C1-C3 alkylene, wherein the C1-C3 alkylene is optionally substituted with 1-3 substituents selected from R2;
• R2 is independently selected at each occurrence from the group consisting of halo, —CN, —NO2, —C1-C6 alkyl, —C1-C6 alkoxy, —C1-C6 fluoroalkyl, —C1-C6 heteroalkyl, and C(O)—C1-C6 alkyl;
• w is 0, 1, or 2;
• x is 0, 1, 2, 3, or 4;
• y is 2, 3, or 4;
• z is 0, 1, 2, or 3;
• and
• m is 0, 1, or 2.