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AssigneesBoard of Regents, The University of Texas System, University of North Texas Health Science Center at Fort Worth
InventorsAnthony J. Di Pasqua, Kenneth J. Balkus, Jr., Imalka S. Munaweera, Yi Shi
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Iron garnet nanoparticles and or iron garnet particles containing various activatable nuclides, such as holmium-165 (165Ho) and dysprosium-164 (164Dy), are disclosed in this application. The iron garnet (e.g., HoIG and DyIG) nanoparticles and iron garnet particles can prepared using hydroxide co-precipitation methods. In some embodiments, radiosensitizers can be loaded on radioactive magnetic nanoparticles or radioactive iron garnet particles and, optionally, coated with suitable lipid bilayers. Methods of using the disclosed nanoparticles and particles for mediating therapeutic benefit in diseases responsive to radiation therapy are also provided. Another aspect of the invention provides films, electrospun fabrics or bandage coverings for the delivery of radiation to the site of a skin lesion amenable to treatment with radiation (e.g., skin cancers or psoriasis).
A method of treating a disorder responsive to a radiotherapeutic agent to in a subject in need thereof, comprising administering to said subject a therapeutically effective amount of an activated iron garnet nanoparticle containing a radionuclide selected from lanthanum-142, praseodymium-142, samarium-153, dysprosium-165, holmium-166, rhenium-186 and/or rhenium-188 and optionally comprising a radiosensitizer, or a pharmaceutical composition thereof, to said subject.
A method of identifying the site of a disorder in a subject in need thereof, comprising administering to said subject an amount of an activated iron garnet nanoparticle containing a radionuclide selected from lanthanum-142, praseodymium-142, samarium-153, dysprosium-165, holmium-166, rhenium-186 and/or rhenium-188 and optionally comprising a radiosensitizer, or a pharmaceutical composition thereof, to said subject, said amount of nanoparticle or particle emitting radiation detectable by an imaging technique selected from magnetic resonance imaging (MRI), X ray computed tomography (CT), Single Photon Emission Computed Tomography (SPECT) and micro-computed tomography (MicroCT).
Dependencies are inferred from the claim text.