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US 10,189,952 B2Granted
Degradable thiol-ene polymers
AssigneeThe Regents of the University of Colorado, a body
InventorsChristopher Bowman, Kristi Anseth, Bilge Hacioglu, Charlie Nuttelman
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Abstract
A thiol-ene polymeric material is disclosed. The material is produced by the photopolymerization of reactants having thiol and olefin moieties. The material can incorporate encapsulated components, including cells. Additionally, the material can be derivatized by reacting the polymeric material with components such as proteins.
Claims45
A method for producing a hydrogel comprising a biocompatible cross-linked degradable thiol-ene polymer, the method comprising:
- subjecting a polymerization reaction mixture comprising at least one thiol compound and at least one olefin compound to a radical polymerization reaction under conditions sufficient to produce the biocompatible cross-linked degradable thiol-ene polymer, wherein
- (a) the at least one thiol compound comprises m number of reactive thiol groups;
- (b) the at least one olefin compound comprises n number of reactive ene groups, wherein at least one of the ene groups is a norbornene moiety;
- and
- (c) each of n and m is an integer of at least 2, provided that the sum of n+m is at least 5.
2 more elements
A method for producing a biocompatible thiol-ene hydrogel, the method comprising
- subjecting a polymerization reaction mixture comprising at least one thiol compound and at least one olefin compound to a radical polymerization reaction under conditions sufficient to produce the biocompatible thiol-ene hydrogel, wherein:
- (a) the at least one thiol compound comprises m number of reactive thiol groups;
- (b) the at least one olefin compound comprises n number of reactive ene groups;
- and
- (c) each of n and m is an integer of at least 2, provided the sum of n+m is at least 5.
2 more elements
Dependencies are inferred from the claim text.