Methods and compositions for inactivating enveloped viruses
AssigneeBiogen MA Inc.
InventorsLynn Edward Conley, Yinying Tao
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Abstract
Aspects of the invention provide therapeutic recombinant protein preparations and methods of preparing therapeutic recombinant protein, which methods include contacting recombinant protein preparations with zwitterionic detergent at or above critical micelle concentration of the detergent.
Claims14
A method of inactivating an enveloped virus in a recombinant protein preparation, the method comprising contacting a recombinant protein preparation that comprises a recombinant protein with N,N-dimethyldodecyclamine N-oxide (LDAO) in an amount sufficient to inactivate the enveloped virus, wherein the amount is at a concentration above critical micelle concentration of the LDAO and does not inhibit biological activity of the recombinant protein.
Dependencies are inferred from the claim text.