Calcineurin inhibitors for use in the treatment of lesional vestibular disorders

A method for restoring or ameliorating the functionality of the vestibular endorgans in a subject affected by a lesional vestibular disorder, comprising the step of systemically administering to the subject a therapeutically effective amount of a pharmaceutical composition consisting essentially of a calcineurin inhibitor,

• wherein the lesional vestibular disorder is selected from the group consisting of drug-induced ototoxicity and excitotoxicity,
• wherein the calcineurin inhibitor is selected from the group consisting of tacrolimus, cyclosporin A, CN585 and their derivatives;
• and
• wherein administration of the calcineurin inhibitor restores or ameliorates the functionality of the vestibular endorgans in the subject affected by a lesional vestibular disorder.