Bacteria engineered for conversion of ethylene to ethanol
AssigneeThe Regents of the University of California
InventorsShota Atsumi, Michael D. Toney, Gabriel M. Rodriguez, Yohei Tashiro, Justin B. Siegel, D. Alexander Carlin, Irina Koryakina, Shuchi H. Desai
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Abstract
The present disclosure provides recombinant bacteria with elevated production of ethanol and/or n-butanol from ethylene. Methods for the production of the recombinant bacteria, as well as for use thereof for production of ethanol and/or n-butanol are also provided.
Claims15
An Escherichia coli bacterium transformed with a heterologous polynucleotide encoding a toluene monooxygenase (TOM) from Pseudomonas mendocina or Burkholderia cepacia and utilizing an endogenous ethylene oxide reductase (EOR), wherein heterologous expression of the TOM and endogenous expression of the EOR results in an increase in production of ethanol as compared to a corresponding bacterium lacking the heterologous polynucleotide.
Dependencies are inferred from the claim text.