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US 10,184,010 B2Granted
Dual-targeting protein binding specifically to DLL4 and VEGF and use thereof
AssigneeAblbio
InventorsDong Heon Lee, Kyung Duk Moon, Yu Bin Choi, Kyung Jae Kang, Dong In Kim, Jin Hyung Ahn, Weon Kyoo You, JinWon Jung
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Abstract
The present invention relates to a novel dual-targeting protein comprising: a protein that binds specifically to delta-like ligand 4 (DLL4); and an antibody that binds specifically to vascular endothelial cell growth factor (VEGF).
Claims14
A dual-targeting protein comprising:
- a protein specifically binding to DLL4, which recognizes a conformational epitope of DLL4 comprising amino acid residues 58-65 and 110-115 of SEQ ID NO:21, and an antibody specifically binding to VEGF(Vascular endothelial growth factor), wherein the protein specifically binding to DLL4 comprises:
- a heavy chain variable region comprising heavy chain CDR1 having the amino acid sequence of SEQ ID NO:2, heavy chain CDR2 having the amino acid sequence of SEQ ID NO:3, and heavy chain CDR3 having the amino acid sequence of SEQ ID NO:4, and
- a light chain variable region comprising light chain CDR1 having the amino acid sequence of SEQ ID NO:5, light chain CDR2 having the amino acid sequence of SEQ ID NO:6, and light chain CDR3 having the amino acid sequence of SEQ ID NO:7.
Dependencies are inferred from the claim text.