2-oxo-1,2-dihydrobenzo[cd]indole compound and use thereof
AssigneeGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences
InventorsYong Xu, Xiaoqian Xue, Yan Zhang, Ming Song
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Abstract
The present invention relates to the technical field of medicinal chemistry, and in particular discloses a 2-oxo-1,2-dihydrobenzo[cd]indole compound and use thereof. The compound and pharmaceutically acceptable salt, isomer, racemate, prodrug, co-crystallized complex, hydrate, and solvate thereof can effectively inhibit the BET bromodomain receptor, and can be used for preparing a medicine for treating cancers, cell proliferative disorders, inflammatory diseases, and autoimmune disorders, sepsis, and viral infections.
Claims5
A 2-oxo-1,2-dihydrobenzo[cd]indole compound having a structure represented by formula I, II, III or IV:
- wherein, R1 is selected from C1-C4 linear or branched alkyl,
- R2 is selected from C1-C7 alkyl, C1-C4 alkylene-R6, C1-C4 alkylene-R7-cyclic ring, —R7-cyclic ring or -cyclic ring,
- R3 is selected from C1-C7 alkyl, C1-C4 alkylene-R6′, C1-C4 alkylene-R7-cyclic ring, —R7-cyclic ring or -cyclic ring,
- R4 is selected from C1-C7 alkyl, C1-C4 alkylene-R6″, C1-C4 alkylene-R7-cyclic ring, —R7-cyclic ring or -cyclic ring,
- R5 is selected from C1-C7 alkyl, C1-C4 alkylene-R6″, C1-C4 alkylene-R7-cyclic ring, —R7-cyclic ring or -cyclic ring,
- wherein R6 is selected from —OR8, —COR8, —CONHR8, —COOR8, —S(O)mR8, —NHCOOR8, —NHCOR8 or —NH2, wherein m is 0 or 2,
- R6′ is selected from —OR8, —COR8, —CONHR8, —COOR8 or —S(O)mR8, wherein m is 0 or 2,
- R6″ is selected from —OR8, —COR8, —CONHR8, —COOR8, —S(O)mR8, —NHCOOR8 or —NHCOR8, wherein m is 0 or 2,
- R8 is selected from hydrogen or C1-C3 alkyl, and
- R7 is selected from —COR9, —COOR9 or —OR9, wherein R9 is selected from C1-C3 alkylene, wherein cyclic ring is selected from C3-C10 cycloalkyl, phenyl, or heterocyclic group, or a pharmaceutically acceptable salt, isomer, racemate, prodrug, cocyrstalline complex, hydrate or solvate thereof.
Dependencies are inferred from the claim text.