Recombinant adeno-associated virus capsids resistant to pre-existing human neutralizing antibodies
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsMark A. Kay, Nicole K. Paulk
Life of this patent
Estimating the term…
Abstract
The present invention relates to variant AAV capsid polypeptides, wherein the variant capsid polypeptides exhibit an enhanced neutralization profile, increased transduction and/or tropism in human liver tissue or hepatocyte cells (i.e., human hepatocyte cells), or both, as compared non-variant parent capsid polypeptides.
Claims36
A variant adeno-associated virus (AAV) capsid polypeptide, wherein said variant AAV capsid polypeptide exhibits increased transduction or tropism in human liver tissue or hepatocyte cells as compared to a non-variant parent capsid polypeptide, wherein said variant AAV capsid polypeptide comprises a sequence selected from the group consisting of AAV-NP84 (SEQ ID NO:2), AAV-NP59 (SEQ ID NO:4), AAV-NP40 (SEQ ID NO:6), and AAV-NP30 (SEQ ID NO:8).
A variant adeno-associated virus (AAV) capsid polypeptide, wherein said variant AAV capsid polypeptide exhibits an enhanced neutralization profile as compared to a non-variant parent capsid polypeptide, wherein said variant AAV capsid polypeptide comprises a sequence selected from the group consisting of AAV-NP84 (SEQ ID NO:2), AAV-NP59 (SEQ ID NO:4), AAV-NP40 (SEQ ID NO:6), and AAV-NP30 (SEQ ID NO:8).
Dependencies are inferred from the claim text.