Method for inducing an immune response and formulations thereof

A method for treating a subject, comprising:

• administering an effective amount of a peptide construct optionally with an adjuvant to the subject or administering an effective amount of matured dendritic cells to the subject, wherein
• the peptide construct has the formula P1-x-P2 or P2-x-P1, wherein P2 is selected from the group consisting of SEQ ID NOs:
• 7-10, 41-46, 53-139 and 190-208 or a modification thereof wherein the modification is a modification to either or both of an N- or C-terminal of the sequence by any one or more of amidation or acylation, P1 is selected from the group consisting of SEQ ID NOs:
• 3-6 and 40, or a modification thereof wherein the modification is a modification to either or both of an N- or C-terminal of the sequence by any one or more of amidation or acylation, and x represents a covalent bond or a divalent linking group;
• and
• the matured dendritic cells are formed by contacting immature dendritic cells or monocytes with the peptide construct having the formula P1-x-P2 or P2-x-P1 under conditions suitable for maturation of the cells to form matured dendritic cells,
• wherein the peptide construct or the matured dendritic cells are administered to the subject prophylactically.

A method for modulating an immune response in a subject, comprising:

• administering an effective amount of a peptide construct optionally with an adjuvant to the subject or administering an effective amount of matured dendritic cells to the subject, wherein
• the peptide construct has the formula P1-x-P2 or P2-x-P1, wherein P2 is selected from the group consisting of SEQ ID NOs:
• 7-10, 41-46, 53-139 and 190-208 or a modification thereof wherein the modification is a modification to either or both of an N- or C-terminal of the sequence by any one or more of amidation or acylation, P1 is selected from the group consisting of SEQ ID NOs:
• 3-6 and 40 or a modification thereof wherein the modification is a modification to either or both of an N- or C-terminal of the sequence by any one or more of amidation or acylation, and x represents a covalent bond or a divalent linking group;
• and
• the matured dendritic cells are formed by contacting immature dendritic cells or monocytes with the peptide construct having the formula P1-x-P2 or P2-x-P1 under conditions suitable for maturation of the cells to form matured dendritic cells,
• wherein the peptide construct or the matured dendritic cells are administered to the subject having an active infection.