Genetically engineered microorganisms for the production of chorismate-derived products
AssigneeLanzatech New Zealand Limited
InventorsJames Bruce Yarnton Haycock Behrendorff, Michael Koepke, Loan Phuong Tran, Wyatt Eric Allen
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Abstract
The invention provides genetically engineered microorganisms and methods for producing chorismate-derived products, such as para-hydroxybenzoic acid, salicylate, 2-aminobenzoate, 2,3-dihydroxybenzoate, and 4-hydroxycyclohexane carboxylic acid. Typically, the microorganism comprises at least one of (a) an exogenous chorismate pyruvate lyase, (b) an exogenous isochorismate synthase, (c) an exogenous isochorismate pyruvate lyase, and (d) a prephenate synthase comprising a disruptive mutation.
Claims24
A genetically engineered C1-fixing bacterium capable of producing at least one chorismate-derived product, wherein the bacterium comprises at least one of:
- a. an exogenous chorismate pyruvate lyase,
- b. an exogenous isochorismate synthase,
- c. an exogenous isochorismate pyruvate lyase, and
- d. a prephenate synthase comprising a disruptive mutation that partially inactivates, fully inactivates, deletes, or knocks out the prephenate synthase.
Dependencies are inferred from the claim text.