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US 10,174,302 B1Granted
Modified L-asparaginase
AssigneesXl-Protein GmbH, Jazz Pharmaceuticals Ireland Limited
InventorsLars Friedrich, Anne O'Donnell
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Abstract
The disclosure provides a modified protein that is a combination of (i) an L-asparaginase and (ii) one or more (poly)peptide(s), wherein the (poly)peptide consists solely of proline and alanine amino acid residues, and methods of preparation and use thereof.
Claims17
A modified fusion protein comprising
- (i) an L-asparaginase comprising the amino acid sequence of SEQ ID NO:
- 1, and
- (ii) one or more polypeptides, wherein the one or more polypeptides comprise the amino acid sequence of SEQ ID NO:
- 7 or 9.
1 more element
Dependencies are inferred from the claim text.