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US 10,174,125 B2Granted
Conjugation reagents
AssigneePolytherics Limited
InventorsAntony Robert Godwin, Stephen James Brocchini
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Abstract
The invention provides compound of the general formula: in which each X independently represents a polymer chain; n represents an integer greater than 1; Q represents a linker; Y represents an amide group; and Z represents either —CH.(CH2L)2 or —C(CH2L)(═CH2), in which each L independently represents a leaving group. The compounds are useful reagents for the conjugation of polymers to proteins, the resulting conjugates being novel and also forming part of the invention.
Claims11
A compound having the general formula:
- in which Q is:
- wherein each X independently represents a polymer chain;
- A is CO or CHOH;
- and
- Pr represents a single protein or peptide bonded via two sulfur atoms derived from a disulfide bond in said protein or peptide.
2 more elements
Dependencies are inferred from the claim text.