Dual mechanism inhibitors for the treatment of disease
AssigneeAerie Pharmaceuticals, Inc.
InventorsMitchell A. deLong, Jill M. Sturdivant, Susan M. Royalty
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Abstract
Provided are compounds that are inhibitors of both rho kinase and of a monoamine transporter (MAT) act to improve the disease state or condition. Further provided are compositions comprising the compounds. Further provided are methods for treating diseases or conditions, the methods comprising administering compounds according to the invention. One such disease may be glaucoma for which, among other beneficial effects, a marked reduction in intraocular pressure (IOP) may be achieved.
Claims31
A compound of Formula (VI):
- or a pharmaceutically acceptable salt thereof;
- wherein
- R4 is methyl;
- and
- n is 2.
A method of treating an eye disease in a subject in need thereof, comprising administering to the subject an effective amount of a compound of Formula (VI):
- or a pharmaceutically acceptable salt thereof;
- wherein
- R4 is methyl;
- and
- n is 2.
A method of reducing intraocular pressure in an eye of a subject in need thereof, comprising administering to the subject an effective amount of a compound of Formula (VI):
- or a pharmaceutically acceptable salt thereof;
- wherein
- R4 is methyl;
- and
- n is 2.
A method of modulating kinase activity in a cell, comprising contacting the cell with an amount effective to modulate kinase activity of a compound of Formula (VI):
- or a pharmaceutically acceptable salt thereof;
- wherein
- R4 is methyl;
- and
- n is 2.
Dependencies are inferred from the claim text.