Methods for the safe administration of imidazole or imidazolium compounds

A method of safely and effectively delivering zoledronic acid to the blood of a human being through repeated oral administration comprising:

• orally administering a pharmaceutical composition comprising the zoledronic acid to the human being at least once a month and no more frequently than once a day;
• wherein the pharmaceutical composition is formed by mixing the zoledronic acid with a diluent, a binder, an excipient, a disintegrating agent, a flavoring agent, or a lubricant, and the pharmaceutical composition contains at least 10% zoledronic acid and less than 10% carboxylic acid salt enhancer by weight;
• wherein the pharmaceutical composition is in the form of a pill, a tablet, or a capsule, and each dose of the pharmaceutical composition contains about 0.11 millimoles to about 1.1 millimoles of the zoledronic acid, in an acid or a salt form;
• and
• wherein the delivered pharmaceutical composition provides zoledronic acid with an oral bioavailability of 1.1% to 2.3% to the blood of the human being, wherein the human being is in a fasted state.