Aziridinyl containing compounds and methods of inactivating nucleic acid molecules using the same
AssigneeZata Pharmaceuticals, Inc.
InventorDavid R. Tabatadze
Life of this patent
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Abstract
Described herein are compositions and compounds having one or more aziridinyl groups, and methods of making the same. The compounds can also have one or more nitrogen atoms that each can be positively charged. The composition and compounds can inactivate one or more nucleic acid molecules (e.g. a DNA and/or a RNA from a pathogen) in a sample. The sample can comprise a blood or blood product (e.g., donated blood). The compositions and compounds can inactivate any nucleic acid present in a blood or blood product, thereby making the blood or blood product safe for use (e.g., in a transfusion).
Claims16
A method of inactivating one or more pathogen nucleic acids in a sample comprising:
- administering a compound having structure (I) to the sample
- wherein R1 is selected from the group consisting of CH3, CH2CH3, CH(CH3)2, and
- wherein R2 is, independently for each occurrence, selected from the group consisting of CH3 and
- wherein a is, independently for each occurrence, 0, 1, 2 or 3, and wherein each occurrence of a is not simultaneously selected to be 0;
- m and n are, independently for each occurrence, 3, 4 or 5;
- or a pharmaceutically acceptable salt, hydrate, or solvate thereof;
- and
- wherein the sample comprises one or more pathogen nucleic acids to be inactivated.
Dependencies are inferred from the claim text.