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US 10,173,208 B2Granted
Highly Z-selective olefin metathesis
AssigneesMassachusetts Institute of Technology, The Trustees of Boston College
InventorsRichard R. Schrock, Annie J. King, Yu Zhao, Margaret M. Flook, Amir H. Hoveyda
Life of this patent
Estimating the term…
Abstract
The present invention relates generally to catalysts and processes for the Z-selective formation of internal olefin(s) from terminal olefin(s) via homo-metathesis reactions.
Claims20
A method comprising:
- providing a catalyst having the structure:
- wherein M is Mo or W;
- R1 is aryl, heteroaryl, alkyl, heteroalkyl, optionally substituted;
- R2 and R3 can be the same or different and are hydrogen, alkyl, alkenyl, heteroalkyl, heteroalkenyl, aryl, or heteroaryl, optionally substituted;
- and
- R4 and R5 can be the same or different and are alkyl, heteroalkyl, aryl, heteroaryl, silylalkyl, or silyloxy, optionally substituted, wherein at least one of R4 or R5 is a ligand containing oxygen bound to M;
- and
- reacting a first molecule comprising a terminal double bond with a second molecule that comprises a terminal double bond in the presence of the catalyst to produce a product comprising an internal double bond, and
- wherein the internal double bond of the product comprises one carbon atom from the terminal bond of the first molecule and one carbon atom from the terminal double bond of the second molecule.
6 more elements
A method comprising:
- providing a catalyst having the structure:
- wherein M is Mo or W;
- R1 is aryl, heteroaryl, alkyl, heteroalkyl, optionally substituted;
- R2 and R3 can be the same or different and are hydrogen, alkyl, alkenyl, heteroalkyl, heteroalkenyl, aryl, or heteroaryl, optionally substituted;
- and
- R4 and R5 can be the same or different and are alkyl, heteroalkyl, aryl, heteroaryl, silylalkyl, or silyloxy, optionally substituted, wherein one of R4 and R5 is a ligand containing oxygen bound to M, optionally substituted, and the other is a ligand containing nitrogen bound to M, optionally substituted;
- and
- reacting a first molecule comprising a terminal double bond with a second molecule that comprises a terminal double bond in the presence of the catalyst to produce a product comprising an internal double bond, and
- wherein the internal double bond of the product comprises one carbon atom from the terminal bond of the first molecule and one carbon atom from the terminal double bond of the second molecule.
6 more elements
Dependencies are inferred from the claim text.