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US 10,172,860 B2Granted
Modulators of toll-like receptors
AssigneeGilead Sciences, Inc.
InventorsManoj C. Desai, Randall L. Halcomb, Paul Hrvatin, Hon Chung Hui, Ryan McFadden, Paul A. Roethle, Hong Yang
Life of this patent
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Abstract
Provided are modulators of TLRs of Formula II: pharmaceutically acceptable salts thereof, compositions containing such compounds, and therapeutic methods that include the administration of such compounds.
Claims9
A compound of the Formula:
- or a pharmaceutically acceptable salt thereof, wherein:
- L1 is —O—, —S—, —S(O)2—, or —S(O)—;
- R1 is alkyl;
- X1 is alkylene;
- D is phenyl;
- L2 is alkylene;
- n is 0;
- R4 and R5 are each independently H;
- and
- R6 and R7, taken together with the nitrogen to which they are both attached, form an unsubstituted 4-6 membered heterocycle, which may contain one or more additional heteroatoms selected from N, O, or S.
7 more elements
Dependencies are inferred from the claim text.