Regenerative prostheses as alternatives to donor corneas for transplantation

A corneal implant having a first surface and a second surface, the corneal implant comprising:

• a matrix part containing a matrix material including a hydrogel of at least one first polymer and at least one second polymer, the first polymer including collagen or collagen mimetic peptide (CMP) provided with methacrylate or acrylate functional groups, the second polymer including a synthetic or a natural polymer having functional groups selected from thiol, acrylate or methacrylate, and the first and second polymers are cross-linked via said functional groups;
• and
• a core part in a central part of the matrix material, the core part including a core material of an interpenetrating network (IPN), the IPN including polymerized olefinic monomers, UV polymerizable monomers or a mixture thereof and the hydrogel of the matrix material, the core material exposed at the first surface and at the second surface, the core part being transparent such that the core part has a light transmission of at least 80% within a wavelength range of 400 nm to 700 nm, the core part being anti-fouling, the core part configured to block or hinder cell migration and vessel ingrowth.