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US 10,166,304 B2Granted
Antibody fragments for detecting cancer and methods of use
AssigneeRegents of the University of Minnesota
InventorsJayanth Panyam, Stephen Kalscheuer
Life of this patent
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Abstract
The present invention relates to diagnostic and therapeutic agents comprising recombinant antibody fragments to bind a protein associated with cancer and methods of use of these diagnostic and therapeutic agents.
Claims24
An immune reagent comprising a first scFv antibody fragment that specifically binds to membrane protein HSPG2 (Perlecan), wherein the first scFv antibody fragment is Clone-6 (SEQ ID NO:2).
An immune reagent comprising
- (a) a heavy chain encoded by a nucleic acid having 100% identity to SEQ ID NO:3 and a light chain encoded by a nucleic acid having 100% identity to SEQ ID NO:5;
- or
- (b) a heavy chain variable region having 100% identity to SEQ ID NO:4 and a light chain variable region having 100% identity to SEQ ID NO:6.
Dependencies are inferred from the claim text.