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US 10,166,243 B1Granted
Optimizing mifepristone levels for cushing'S patients
AssigneeCorcept Therapeutics, Inc.
InventorsJoseph Belanoff, Coleman Gross
Life of this patent
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Abstract
The present invention provides a method for optimizing levels of mifepristone in a patient suffering from Cushing's syndrome. The method comprises the steps of treating the patient with seven or more daily doses of mifepristone over a period of seven or more days; testing the serum levels of the patient to determine whether the blood levels of mifepristone are greater than 1631 ng/mL; and adjusting the daily dose of the patient to achieve mifepristone blood levels greater than 1631 ng/mL.
Claims20
A method of treating hypercortisolism in a patient, the method comprising:
- administering an initial daily dose of mifepristone to said patient, said initial daily dose comprising an initial dose amount of mifepristone;
- adjusting the dose amount of mifepristone to provide an adjusted daily dose of mifepristone if the plasma mifepristone level of the patient is less than 2000 ng/mL after administration of said initial daily dose of mifepristone, wherein said adjusting is performed in order to achieve a mifepristone plasma level of at least 2000 ng/mL;
- and
- administering to the patient said adjusted daily dose of mifepristone;
- with the proviso that the patient is not already suffering from a condition indicated for treatment with mifepristone,
- thereby treating hypercortisolism in the patient by achieving a mifepristone plasma level of at least 2000 ng/mL.
3 more elements
Dependencies are inferred from the claim text.