TRPV1 modulatory gene product that affects TRPV1-specific pain behavioral responses identified in a functional screen of an HSV-based cDNA library
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsWilliam F. Goins, Joseph C. Glorioso, III, Justus Bernard Cohen, Bonnie L. Reinhart
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Abstract
The invention provides a method for ameliorating chronic pain signaling involving transient receptor potential cation channel subfamily V member 1 (TRPV1) by expressing PP1α in neurons. The invention also provides HSV vectors for expressing PP1α within neurons and compositions comprising such vectors.
Claims15
A method comprising administering a pharmaceutical composition comprising a pharmaceutically-acceptable carrier and herpes simplex virus (HSV) vectors comprising an expression cassette, which expression cassette comprises a nucleic acid sequence encoding PP1α operably linked to a promoter, to a mammal in an amount and at a location sufficient to result in HSV vectors within the composition to infect peripheral neurons associated with the sensation of pain, such that the nucleic acid sequences encoding PP1α within said vectors are transcribed within the neurons to produce PP1α within the neurons.
Dependencies are inferred from the claim text.